Ovatoxin-a

Palytoxin is a highly toxic non-proteinaceous marine natural product that can pass through the food chain and result in human illnesses. A recent review by the European Food Safety Authority concluded that palytoxin requires regulation in seafood and a limit of 30 μg kg⁻¹ for shellfish flesh was sug …

This was achieved by setting up a new analytical method for detecting palytoxin 26 Jul 2016 The most abundant palytoxin analogues in Mediterranean strains, Ovatoxin-a ( OVTX-a) and its analogues, can accumulate in several marine In the last decades, the highly toxic palytoxins (PLTXs; mainly the analogue ovatoxin-a) were frequently identified in the Mediterranean Sea during Ostreopsis cf. Ovatoxin-a and palytoxin accumulation in seafood in relation to Ostreopsis cf. ovata blooms on the French Mediterranean coast. Z Amzil, M Sibat, N Chomerat, 15 Mar 2018 Ovatoxin-a was found at the concentration of 78.8 µg/kg only in the soft tissue extract of T0 sea urchins, while the toxin was not detected in C Ovatoxin-a and Palytoxin Accumulation in Seafood in.

29.05.2021

This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf. ovata in the Mediterranean Sea. 3/4/2015 Sigma-Aldrich offers abstracts and full-text articles by [Charline Brissard, Fabienne Hervé, Manoella Sibat, Véronique Séchet, Philipp Hess, Zouher Amzil, Christine Herrenknecht]. On the basis of molecular formula, fragmentation pattern, and chromatographic behavior, the structure of ovatoxin-a appeared to be strictly related to that of palytoxin. We report also on the analysis of cultured O. ovata, which was necessary to unequivocally demonstrate that putative palytoxin and ovatoxin-a contained in field samples were actually produced by O. ovata itself. Among the OVTXs so far detected by high-resolution liquid chromatography coupled to mass spectrometry (HR- LC-MS), ovatoxin-a (OVTX-a) has emerged as the major toxin produced by O. ovata.[3] It was successfully isolated from O. ovata cultures and structurally identified as a paly- toxin analogue by means of NMR techniques.

2 Feb 2016 This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major

doi: 10.3390/md10020477. Epub 2012 Feb 17.

Nov 24, 2008 · Two of the most remarkable properties of palytoxin are the large and complex structure (with different analogs, such as ostreocin‐D or ovatoxin‐a) and the extreme acute animal toxicity. The Na + /K + ‐ATPase has been proposed as receptor for palytoxin.

We've detected an unusually high number of searches coming from your location. Are you a real person, or a robot? P. Ciminiello, C. Dell'Aversano, E. Fattorusso et al., “Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the ligurian coasts during the 2006 toxic outbreak,” Journal of the American Society for Mass Spectrometry, vol. 19, no. 1, pp.

2006 (Ciminiello et al.

Authors Zouher 1/1/2008 Abstract. This study provides the first evaluation of the cytotoxic effects of the recently identified palytoxin (PLTX) analog, ovatoxin-a (OVTX-a), the major toxin produced by Ostreopsis cf. ovata in the Mediterranean Sea. 3/4/2015 Sigma-Aldrich offers abstracts and full-text articles by [Charline Brissard, Fabienne Hervé, Manoella Sibat, Véronique Séchet, Philipp Hess, Zouher Amzil, Christine Herrenknecht]. On the basis of molecular formula, fragmentation pattern, and chromatographic behavior, the structure of ovatoxin-a appeared to be strictly related to that of palytoxin. We report also on the analysis of cultured O. ovata, which was necessary to unequivocally demonstrate that putative palytoxin and ovatoxin-a contained in field samples were actually produced by O. ovata itself. Among the OVTXs so far detected by high-resolution liquid chromatography coupled to mass spectrometry (HR- LC-MS), ovatoxin-a (OVTX-a) has emerged as the major toxin produced by O. ovata.[3] It was successfully isolated from O. ovata cultures and structurally identified as a paly- toxin analogue by means of NMR techniques.

Ovatoxin A | C129H223N3O52 | CID 90479618 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities OVTX-a is about 100 fold less potent than PLTX in reducing HaCaT cells viability (EC 50 = 1.1 × 10 –9 M vs 1.8 × 10 –11 M, MTT test) in agreement with a reduced binding affinity (Kd = 1.2 × 10 –9 vs 2.7 × 10 –11 M, saturation experiments on intact cells). Feb 17, 2012 · The ovatoxin was quantified using the PLTX standard. The maximum levels found in terms of total PLTX equivalents (PLTX and ovatoxin-a) were approximately 175 µg and 450 µg eq PLTX/kg of total sea urchin flesh, in Iles de Frioul (August 2008) and Villefranche-sur-Mer (July 2008), respectively. 1009813-91-5 - RZASWFCAHPACCD-FAXBYDSISA-N - Ovatoxin A - Similar structures search, synonyms, formulas, resource links, and other chemical information. Results from 2008 and 2009 showed that there is a real danger of human poisoning, as these demonstrated bioaccumulation of the PLTX group (PLTX and ovatoxin-a) in both filter-feeding bivalve molluscs (mussels) and herbivorous echinoderms (sea urchins).

The Na + /K + ‐ATPase has been proposed as receptor for palytoxin. Apr 04, 2011 · Ciminiello P, Dell'Aversano C, Fatturosso E, Forino M, Tartaglione L, et al. (2008) Putative palytoxin and its analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak. J Am Soc Mass Spectrom 19: 111–120.

Geoditin A, an isomalabaricane triterpene isolated from marine sponge Geodia japonica, has been demonstrated to induce apoptosis in leukemia HL60 cells and human colon HT29 cancer cells through an oxidative stress, a process also interfering with normal melanogenesis in pigment cells. Treatment of murine melanoma B16 cells with geoditin A decreased expression of melanogenic proteins and cell 1009813-91-5 - RZASWFCAHPACCD-FAXBYDSISA-N - Ovatoxin A - Similar structures search, synonyms, formulas, resource links, and other chemical information.

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A formerly unknown derivative of palytoxin, ovatoxin-a, produced as a marine aerosol by the tropical dinoflagellate Ostreopsis ovata caused hundreds of people in Genoa, Italy, to fall ill. In 2005 and 2006 blooms of these algae occurred in the Mediterranean sea. All those affected needed hospitalization.

All those affected needed hospitalization. 22/2/2012 Abstract Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and Abstract Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and 10/12/2014 Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and environmental suffering. Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three Palytoxin is a highly toxic non-proteinaceous marine natural product that can pass through the food chain and result in human illnesses.

The ovatoxin was quantified using the PLTX standard. The maximum levels found in terms of total PLTX equivalents (PLTX and ovatoxin-a) were approximately 175 µg and 450 µg eq PLTX/kg of total sea urchin flesh, in Iles de Frioul (August 2008) and Villefranche-sur-Mer (July 2008), respectively.

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22/2/2012 Abstract Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and Abstract Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and 10/12/2014 Ovatoxin‐a is the main toxin produced by Ostreopsis ovata, a benthic dinoflagellate that has bloomed massively across the Mediterranean basin over the past years, inflicting both human and environmental suffering. Ovatoxin‐a has recently been isolated from cultures of O. ovata and structurally identified as an analogue of palytoxin: in comparison with palytoxin, ovatoxin‐a lacks three Palytoxin is a highly toxic non-proteinaceous marine natural product that can pass through the food chain and result in human illnesses. A recent review by the European Food Safety Authority concluded that palytoxin requires regulation in seafood and a limit of 30 μg kg⁻¹ for shellfish flesh was sug … Putative palytoxin and its new analogue, ovatoxin-a, in Ostreopsis ovata collected along the Ligurian coasts during the 2006 toxic outbreak Sommaire In this article we report on the liquid chromatography tandem mass spectrometry (LC-MS) investigation of plankton samples collected in the summer of 2006 along the Ligurian coasts, coinciding with a massive bloom of the tropical microalga LC–MS analysis suggests that ovatoxin-a AC is dideoxy-42-hydroxy-44-deoxy-palytoxin. The unidentified deoxy-positions can be assigned both between C16 and C20 and between C53 and C73. Toxin profiles of Ostreopsis collected in the middle to southern coastal area in Japan were similar irrespective of clades classified by the phylogenetic analysis reported in our previous study. Currently, the benthic dinoflagellate Ostreopsis cf. ovata represents a serious concern to human health in the whole Mediterranean basin due to the production of palytoxin congeners, a putative palytoxin and ovatoxins (ovatoxin-a, -b, -c, -d/-e), listed among the most potent marine toxins.